Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.

Maria Vittoria Micioni Di BonaventuraMariangela PucciMaria Elena GiusepponiAdele RomanoCatia LambertucciRosaria VolpiniEmanuela Micioni Di BonaventuraSilvana GaetaniMauro MaccarroneClaudio D'AddarioCarlo Cifani

Published in: Journal of psychopharmacology (Oxford, England) (2019)

We confirm the role of A2AAR in binge eating behaviours, and we underline the importance of epigenetic regulation of the A2AAR gene, possibly due to a compensatory mechanism to counteract the effect of binge eating. We suggest that A2AAR activation, inducing receptor gene up-regulation, could be relevant to reduction of food consumption.

Keyphrases

gene expression
weight loss
physical activity
genome wide
copy number
dna methylation
genome wide identification
risk assessment
human health