Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria.

Ogochukwu AmaezeHeather EngLauren HorlbogenManthena V S VarmaAngela L Slitt

Published in: European journal of drug metabolism and pharmacokinetics (2021)

The medicinal plants inhibited CYP activity in vitro, with the potential to cause in vivo HDI. Clinical risk assessment and proactive monitoring are recommended for patients who use these medicinal plants concurrently with drugs that are cleared through CYP metabolism.

Keyphrases

risk assessment
human health
type diabetes
cardiovascular disease
heavy metals
emergency department
glycemic control
drug induced
metabolic syndrome
skeletal muscle
climate change
adverse drug