Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic review.

Shahram Darabi Armin Aryannejad Auob Rustamzadeh Dariush Afshari Enam Alhagh Charkhat Gorgich Leila Darabi

Published in: Diagnostic pathology (2024)

Based on the results, each biomarker alone is insufficient to evaluate ALS. CNS-derived exosomes contain multiple ALS-related biomarkers (SOD1, TDP-43, pTDP-43, FUS, and miRNAs) that are detectable in cerebrospinal fluid and blood is a proper alternation. Exosome detecting kits listed as exoEasy, ExoQuick, Exo-spin, ME kit, ExoQuick Plus, and Exo-Flow, are helpful to reach this purpose.

Keyphrases

amyotrophic lateral sclerosis
cerebrospinal fluid
mesenchymal stem cells
stem cells
single molecule
room temperature
density functional theory
bone marrow