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Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic review.

Shahram DarabiArmin AryannejadAuob RustamzadehDariush AfshariEnam Alhagh Charkhat GorgichLeila Darabi
Published in: Diagnostic pathology (2024)
Based on the results, each biomarker alone is insufficient to evaluate ALS. CNS-derived exosomes contain multiple ALS-related biomarkers (SOD1, TDP-43, pTDP-43, FUS, and miRNAs) that are detectable in cerebrospinal fluid and blood is a proper alternation. Exosome detecting kits listed as exoEasy, ExoQuick, Exo-spin, ME kit, ExoQuick Plus, and Exo-Flow, are helpful to reach this purpose.
Keyphrases
  • amyotrophic lateral sclerosis
  • cerebrospinal fluid
  • mesenchymal stem cells
  • stem cells
  • single molecule
  • room temperature
  • density functional theory
  • bone marrow