Likely causal effects of insulin resistance and IGF-1 bioaction on childhood and adult adiposity: a Mendelian randomization study.
Duaa I OlwiLena R KaisingerKatherine A KentistouMarc VaudelStasa StankovicPal Rasmus NjolstadStefan JohanssonJohn R B PerryFelix R DayKen K OngPublished in: International journal of obesity (2005) (2024)
Genetic causal modelling indicates negative effects of insulin resistance on childhood and adult adiposity, and negative effects of IGF-1 resistance on childhood adiposity. Our findings demonstrate the need to distinguish between bioaction and resistance when modelling variants associated with biomarker concentrations.
Keyphrases
- insulin resistance
- childhood cancer
- adipose tissue
- high fat diet
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- early life
- high fat diet induced
- young adults
- copy number
- pi k akt
- binding protein
- genome wide
- weight gain
- glycemic control
- growth hormone
- signaling pathway
- cell proliferation
- gene expression
- weight loss