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Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating CD9 and PLEKHG6.

Juntao KeJianbo TianShufang MeiPingting YingNan YangXiaoyang WangDanyi ZouXiating PengYang YangYing ZhuYajie GongZhihua WangJing GongRong ZhongJiang ChangXiaoping Miao
Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2020)
These findings suggest a novel insight for genetic pathogenesis of colon and rectal adenocarcinoma, involving transcriptional coactivation of diverse susceptibility genes via the SE element as a gene regulation hub.
Keyphrases
  • genome wide
  • rectal cancer
  • locally advanced
  • squamous cell carcinoma
  • transcription factor
  • bioinformatics analysis
  • copy number
  • dna methylation
  • gene expression
  • binding protein
  • radiation therapy
  • heat shock
  • nk cells