Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.

Alberto ServettoRahul KolliparaLuigi FormisanoChang-Ching LinKyung-Min LeeDhivya R Sudhan Paula I Gonzalez Ericsson Sumanta Chatterjee Angel L Guerrero-ZotanoSaurabh MendirattaHiroaki AkamatsuNicholas JamesRoberto Bianco Ariella B Hanker Ralf KittlerCarlos L Arteaga

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These data suggest nuclear FGFR1 contributes to endocrine resistance by modulating gene transcription in ER+ breast cancer. Nuclear FGFR1 activity was unaffected by FGFR TKIs, thus supporting the development of treatment strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.

Keyphrases

estrogen receptor
transcription factor
genome wide
copy number
signaling pathway
gene expression
machine learning
electronic health record
dna methylation
genome wide identification
young adults
breast cancer risk
deep learning
data analysis