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Late drug-resistance in mild MTLE: Can it be influenced by preexisting white matter alterations?

Angelo LabateMaria Eugenia CaligiuriFrancesco FortunatoEdoardo FerlazzoUmberto AgugliaAntonio Gambardella
Published in: Epilepsia (2020)
White matter temporal and extratemporal abnormalities are preexisting in patients with mild MTLE who will develop drug-resistance, independently from the presence of Hs. Thus, these changes might be due to an inherited genetic alteration rather than a subordinate worsening after repeated seizures, multiple antiepileptic drugs, or initial precipitating factors.
Keyphrases
  • white matter
  • multiple sclerosis
  • genome wide
  • copy number
  • gene expression
  • dna methylation