Detection of BRAFV600E by digital PCR on fine-needle aspirate enables rapid initiation of dabrafenib and trametinib in unresectable anaplastic thyroid carcinoma.
Camille BuffetLucie AllardErell GuillermCécile GhanderElise MathyCharlotte Lussey-LepoutreNicolas JulienEliane ToumaPauline QuilhotGaelle Godiris-PetitJean-Marc LacorteLaurence LeenhardtJerome Alexandre DenisPublished in: European journal of endocrinology (2022)
We suggest that ddPCR on FNA be used in non-resectable cervical masses for rapid BRAFV600E mutation detection in the hope that starting targeted therapies early might improve outcomes.