HER2 status and response to neoadjuvant anti-HER2 treatment among patients with breast cancer and Li-Fraumeni syndrome.

Michele BottossoRenata L SandovalBenjamin VerretNatalia PolidorioOlivier CaronAlessandra GennariBrittany L BychkovskySophie H CahillMaria I AchatzValentina GuarneriFabrice AndréJudy E Garber

Published in: European journal of cancer (Oxford, England : 1990) (2024)

Among females with LFS and BC, HER2-positive subtype was associated with younger age at diagnosis and a predominant HR-positivity. Favorable pCR rates were observed among those receiving neoadjuvant HER2-directed therapies, for both HR-positive and negative tumors. These data may inform the counseling and care of patients with LFS.

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