Current Knowledge of MicroRNAs (miRNAs) in Acute Coronary Syndrome (ACS): ST-Elevation Myocardial Infarction (STEMI).
Daniela Maria TănaseEvelina Maria GosavAnca OuatuMinerva Codruta BadescuNicoleta DimaAna Roxana Ganceanu-RusuDiana PopescuMariana FloriaElena RezusCiprian RezusPublished in: Life (Basel, Switzerland) (2021)
Regardless of the newly diagnostic and therapeutic advances, coronary artery disease (CAD) and more explicitly, ST-elevation myocardial infarction (STEMI), remains one of the leading causes of morbidity and mortality worldwide. Thus, early and prompt diagnosis of cardiac dysfunction is pivotal in STEMI patients for a better prognosis and outcome. In recent years, microRNAs (miRNAs) gained attention as potential biomarkers in myocardial infarction (MI) and acute coronary syndromes (ACS), as they have key roles in heart development, various cardiac processes, and act as indicators of cardiac damage. In this review, we describe the current available knowledge about cardiac miRNAs and their functions, and focus mainly on their potential use as novel circulating diagnostic and prognostic biomarkers in STEMI.
Keyphrases
- percutaneous coronary intervention
- st elevation myocardial infarction
- acute coronary syndrome
- st segment elevation myocardial infarction
- coronary artery disease
- antiplatelet therapy
- coronary artery bypass grafting
- left ventricular
- healthcare
- end stage renal disease
- heart failure
- oxidative stress
- chronic kidney disease
- atrial fibrillation
- newly diagnosed
- ejection fraction
- type diabetes
- prognostic factors
- working memory
- risk assessment
- aortic stenosis
- human health
- patient reported