Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis.
Meng-Jie ZhangMeng-Yun LiangShao-Chen YangXian-Bin MaShu-Cheng WanQi-Chao YangShuo WangZhigang XuZhi-Jun SunPublished in: Chemical communications (Cambridge, England) (2023)
Glutathione-responsive nanogels (CDNPs) crosslinked via crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with αPD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.