Magnetic Forces by Permanent Magnets to Manipulate Magnetoresponsive Particles in Drug-Targeting Applications.

This study presents preliminary computational and experimental findings on two alternative permanent magnet configurations helpful for magnetic drug administration in vivo. A numerical simulation and a direct experimental measurement of the magnetic induction on the magnet system's surface were used to map the magnetic field. In addition, the ferrite-type (grade Y35) and permanent neodymium magnets (grade N52) to produce powerful magnetic forces were also examined analytically and quantitatively. Ansys-Maxwell software and Finite Element Method Magnetism (FEMM) version 4.2 were used for all numerical computations in the current investigation. For both magnets, the generated magnetic fields were comparatively studied for targeting Fe particles having a diameter of 6 μm. The following findings were drawn from the present investigation: (i) the particle deposition on the vessel wall is greatly influenced by the intensity of the magnetic field, the magnet type, the magnet size, and the magnetic characteristics of the micro-sized magnetic particles (MSMPs); (ii) ferrite-type magnets might be employed to deliver magnetoresponsive particles to a target location, even if they are less powerful than neodymium magnets; and (iii) the results from the Computational Fluid Dynamics( CFD) models agree well with the measured magnetic field induction, magnetic field strength, and their fluctuation with the distance from the magnet surface.