Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents.

Conor J O'HanlonAnita SumpterBrian Joseph Anderson Jacqueline A Hannam

Published in: Clinical pharmacokinetics (2024)

Milrinone is predominately renally eliminated and so renal function is an important covariate describing variability in clearance. Increasing clearance over time likely reflects increasing cardiac output and renal perfusion due to milrinone and return to baseline following CPB.

Keyphrases

young adults
physical activity
left ventricular
low birth weight
heart failure
magnetic resonance
computed tomography
atrial fibrillation