Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy.

Bertrand LebouchéAlexis YeroTao ShiOmar FarnosJoel SingerIdo KemaCecilia T CostiniukRéjean ThomasMarie-Josée BrouilletteKim EnglerJean-Pierre RoutyMohammad-Ali Jenabiannull null

Published in: HIV research & clinical practice (2021)

Conclusions: Although ER-niacin combined with ART was well-tolerated among immune non-responders and decreased plasma lipids, it did not improve systemic inflammation, Kyn/Trp ratio, and CD4 cell recovery. Overall, ER-niacin was not effective to overcome chronic inflammation in PLWH.

Keyphrases

hiv infected
antiretroviral therapy
human immunodeficiency virus
hiv infected patients
hiv positive
hiv aids
endoplasmic reticulum
estrogen receptor
oxidative stress
single cell
breast cancer cells
stem cells
bone marrow