Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.
Siddhartha YadavChunling HuKatherine L NathansonJeffrey N WeitzelDavid E GoldgarPeter KraftRohan D GnanaolivuJie NaHongyan HuangNicholas J BoddickerNicole LarsonChi GaoSong YaoClarice WeinbergCeline M VachonAmy Trentham-DietzJack A TaylorDale R SandlerAlpa PatelJulie R PalmerJanet E OlsonSusan L NeuhausenMaría Elena MartínezSara LindstromJames V LaceyAllison W KurianIsabelle DurotChristopher HaimanLeslie BernsteinPaul W AuerHoda Anton-CulverChristine B AmbrosoneRachid KaramElizabeth ChaoAmal YussufTina PesaranJill S DolinskySteven N HartHolly LaDucaEric C PolleySusan M DomchekFergus J CouchPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
The study establishes that PVs in ATM, BRCA2, CDH1, CHEK2, and PALB2 are associated with an increased risk of ILC, whereas BRCA1 PVs are not. The similar overall PV frequencies for ILC and IDC suggest that cancer histology should not influence the decision to proceed with genetic testing. Similar to IDC, multigene panel testing may be appropriate for women with ILC, but CDH1 should be specifically discussed because of low prevalence and gastric cancer risk.