Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain.

Pedro Augusto Lopes TitoTúlio Cézar de Souza BernardinoPaula Maria Quaglio BelloziMaria Carolina Machado da SilvaAline Silva de MirandaÉrica Leandro Marciano VieiraFabrício A MoreiraAndrás PalotásAntônio Carlos Pinheiro de OliveiraHelton José Reis

Published in: Pharmacological reports : PR (2021)

Apparently, CBD prevents both behavioral and neuro-immunological changes associated with LPS-induced SB, which reinforces its potential use as an antidepressant which modulates neuroinflammation. This opens up potentially new therapeutic avenues in MDD.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
major depressive disorder
mouse model
white matter
resting state
bipolar disorder
traumatic brain injury
functional connectivity
cognitive impairment
brain injury
blood brain barrier