Determinants of renin cell differentiation: a single cell epi-transcriptomics approach.

Alexandre G MartiniJason P SmithSilvia MedranoNathan C SheffieldMaria Luisa S Sequeira-LopezR Ariel Gomez

Published in: bioRxiv : the preprint server for biology (2023)

We provide the first developmental trajectory of renin cell differentiation as they become JG cells in a single-cell atlas of kidney vascular open chromatin and highlighted novel factors important for their stage-specific differentiation. This improved understanding of the regulatory landscape of renin expressing JG cells is necessary to better learn the control and function of this rare cell population as overactivation or aberrant activity of the RAS is a key factor in cardiovascular and kidney pathologies.

Keyphrases

single cell
rna seq
induced apoptosis
high throughput
cell cycle arrest
transcription factor
dna damage
gene expression
cell death
angiotensin converting enzyme
oxidative stress
endoplasmic reticulum stress
minimally invasive
signaling pathway
mesenchymal stem cells