Integrated bioinformatics analysis reveals upregulated extracellular matrix hub genes in pancreatic cancer: Implications for diagnosis, prognosis, immune infiltration, and therapeutic strategies.

Md Roman MogalJasmin Akter JameMd Sohel Md MozibullahMd Rashel MahmodAsadullah JunayedNewton KarLubatul ArbiaAbdullah Al Mamun Md Asaduzzaman Sikder

Published in: Cancer reports (Hoboken, N.J.) (2024)

Taken together, our findings suggest that COL1A1, KRT19, MMP1, COL11A1, SDC1, ITGA2, COL1A2, POSTN, FN1, and COL5A1 hold promise as innovative biomarkers for both the diagnosis and prognosis of PC, and they present as prospective targets for therapeutic interventions aimed at impeding the progression PC.

Keyphrases

bioinformatics analysis
extracellular matrix
physical activity
big data
gene expression