Therapeutic Monitoring of Palbociclib, Ribociclib, Abemaciclib, M2, M20, and Letrozole in Human Plasma: A Novel LC-MS/MS Method.

Bianca PosoccoMartina ZanchettaMarco OrleniSara GagnoMarcella MonticoElena PeruzziRossana RoncatoLorenzo GerratanaSerena CorsettiFabio PuglisiGiuseppe Toffoli

Published in: Therapeutic drug monitoring (2024)

A simple and robust LC-MS/MS method was successfully validated for the simultaneous quantification of CDK4/6is, M2, M20, and letrozole in human plasma. The assay was found to be suitable for measuring steady-state trough concentrations of the analytes in patient samples.

Keyphrases

polycystic ovary syndrome
early breast cancer
case report
cell cycle
adipose tissue
skeletal muscle
metabolic syndrome