Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children.

William B SherwoodVictoria BionGabrielle A LockettAli H ZiyabNelís Soto-RamírezNandini MukherjeeRamesh J KurukulaaratchySusan EwartHongmei ZhangS Hasan ArshadWilfried KarmausJohn W HollowayFaisal I Rezwan

Published in: Clinical epigenetics (2019)

Breastfeeding duration is associated with LEP methylation at age 10 years and BMI trajectory. LEP DNAm is also significantly associated with BMI trajectories throughout childhood, though sample sizes were small. However, mediation analysis did not demonstrate that DNAm of LEP explained the protective effect of breastfeeding against childhood obesity.

Keyphrases

dna methylation
body mass index
preterm infants
weight gain
genome wide
gene expression
depressive symptoms
nk cells
physical activity
copy number