Evaluation of life cycle defective adenovirus mutants for production of adeno-associated virus vectors.

Alexandra Krüger-HaagCaroline LehmannErika SchmidtFlorian SonntagMarkus HörerStefan Kochanek

Published in: The journal of gene medicine (2019)

The present study indicates the advantages of using a ∆pTP mutant adenovirus rather than adenovirus wild-type as a helper virus for AAV2 production and also indicates that temperature shifts to lower temperatures may improve AAV2 vector production rates.

Keyphrases

gene therapy
wild type
life cycle
dendritic cells
immune response