Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions.

Özlem AkmanStephen W BriggsWenzhu B MowreySolomon L Moshé Aristea S Galanopoulou

Published in: Epilepsia (2021)

Structural corticohippocampal/basal ganglia lesions increase the risk for post-infantile spasms epilepsy, Lennox-Gastaut syndrome features, and sleep dysregulation. Pulse rapamycin treatment for infantile spasms has anti-epileptogenic effects, despite the structural lesions, and decreases the time spent in slow wave sleep.

Keyphrases

physical activity
sleep quality
blood pressure
case report
depressive symptoms