The virulence factor GroEL directs the osteogenic and adipogenic differentiation of human periodontal ligament stem cells through the involvement of JNK/MAPK and NF-κB signaling.
Li ZhangLei ChengYujia CuiZuping WuLinyi CaiLiu YangMengmeng DuanDemao ZhangChenchen ZhouJing XiePublished in: Journal of periodontology (2021)
In the current study, we revealed a potential interaction between bacteria and host cells by showing that GroEL directs the osteogenic and adipogenic differentiation of hPDLSCs by the involvement of JNK/MAPK and NF-κB signaling. This study provides evidence that bacterial products can influence the differentiation of stem cells and reveals potential effect of GroEL on the context of tissue regeneration.
Keyphrases
- stem cells
- signaling pathway
- induced apoptosis
- oxidative stress
- pi k akt
- mesenchymal stem cells
- bone marrow
- escherichia coli
- cell death
- endothelial cells
- pseudomonas aeruginosa
- staphylococcus aureus
- immune response
- risk assessment
- cystic fibrosis
- climate change
- toll like receptor
- endoplasmic reticulum stress
- single cell