Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model.

Ishita TandonShelby JohnsAlan WoessnerJessica PerezDelaney CrossAsya OzkizilcikTimothy J MuldoonSrikanth VallurupalliMuralidhar PadalaKyle P QuinnKartik Balachandran

Published in: BMC cardiovascular disorders (2020)

This study suggests the potential of TPEF autofluorescence metrics to serve as a label-free tool for early detection and monitoring of CAVD pathophysiology.

Keyphrases

label free
aortic valve
wild type
mouse model
transcatheter aortic valve replacement
aortic valve replacement
transcatheter aortic valve implantation
aortic stenosis
high resolution
risk assessment
heart failure
left ventricular
ejection fraction