Neuropeptide W facilitates chronic gastric ulcer healing by the regulation of cyclooxygenase and NF-κB signaling pathways.
Sevil Arabacı TamerKadriye Sezen MermerÖmer ErdoğanÖzge ÇevikFeriha ErcanCahit BağcıTessa Corrine Catherina JaspersPublished in: Inflammopharmacology (2024)
In conclusion, NPW facilitated the healing of gastric injury in rats via the inhibition of pro-inflammatory cytokine production, oxidative stress and neutrophil infiltration as well as the downregulation of COX-2 protein and NF-κB gene expressions.
Keyphrases
- signaling pathway
- oxidative stress
- pi k akt
- induced apoptosis
- lps induced
- epithelial mesenchymal transition
- cell proliferation
- dna damage
- copy number
- genome wide
- ischemia reperfusion injury
- diabetic rats
- nuclear factor
- protein protein
- inflammatory response
- genome wide identification
- dna methylation
- gene expression
- binding protein
- small molecule
- transcription factor
- immune response
- nitric oxide