Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes.
Taiki MiyazawaReina KamiyoshiharaNaoki ShimizuTakahiro HarigaeYurika OtokiJunya ItoShunji KatoTeruo MiyazawaKiyotaka NakagawaPublished in: Royal Society open science (2018)
Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.