Disease-induced and treatment-induced alterations in body composition in locally advanced head and neck squamous cell carcinoma.
Anna C H WillemsenAnn HoebenRoy I LalisangArdy van HelvoortFrederik W R WesselingFrank J P HoebersLaura W J BaijensAnnemie M W J ScholsPublished in: Journal of cachexia, sarcopenia and muscle (2019)
In LAHNSCC patients undergoing CRT/BRT, FFMI < P10 is an unfavourable prognostic factor for overall survival, treatment toxicity, and tolerance. Patients experience significant weight and FFM loss during treatment. Current TF regime attenuates weight loss but does not overcome loss of muscle mass and function during therapy. Future interventions should consider nutritional intake and additional strategies specifically targeting metabolism, loss of muscle mass, and function.
Keyphrases
- body composition
- prognostic factors
- weight loss
- patients undergoing
- end stage renal disease
- locally advanced
- physical activity
- squamous cell carcinoma
- chronic kidney disease
- bariatric surgery
- newly diagnosed
- resistance training
- body mass index
- bone mineral density
- weight gain
- radiation therapy
- stem cells
- heart failure
- peritoneal dialysis
- neoadjuvant chemotherapy
- clinical trial
- combination therapy
- gastric bypass
- bone marrow
- high intensity
- roux en y gastric bypass
- cancer therapy
- patient reported