Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population.
Thamiris CirelliRafael NepomucenoJéssica Marina GoveiaSilvana R P OrricoJoni A CirelliLetícia Helena TheodoroSilvana P BarrosRaquel Mantuaneli Scarel CaminagaPublished in: Clinical oral investigations (2021)
Polymorphisms in the CDKAL1-rs7754840, HNF1A-rs7957197, RPSAP52-rs1531343, TCF7L2-rs7903146, and CDKN2B-rs7018475 might predispose to periodontitis and T2DM associated with periodontitis. These findings may be useful in public health genomics and future advanced clinical practice, since genetic carriage can be measured before disease onset, being of potential great benefit for treatment planning and prognosis in early disease stages.