ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway.

Qiang Wang Zhiqiang Gao Kai Guo Jiawei Lu Feng Wang Yu-Feng Huang Desheng Wu

Published in: Journal of orthopaedic surgery and research (2022)

The inhibition of MKK3/p38 MAPK/PCNA pathway plays an important role in the development of osteoporosis caused by Enpp1 deficiency, and LPA partially rescued the proliferation of pre-osteoblasts via the MKK3/p38 MAPK/PCNA pathway.

Keyphrases

signaling pathway
postmenopausal women
bone mineral density
pi k akt
epithelial mesenchymal transition
induced apoptosis
body composition
endoplasmic reticulum stress
smoking cessation