Machaerium acutifolium compounds with larvicidal activity against Aedes aegypti.
Sebastião J DE MeloJoão Paulo B SousaMaíra G SáLais Silva MoraisNatália Mg MagalhãesFernando N GouveiaLorena Carneiro AlbernazLaila Salmen EspindolaPublished in: Pest management science (2020)
A M. acutifolium extract showed larvicidal activity, which increased with prolonged exposure, demonstrating LC50 75 mg L-1 after 72 h. Although the flavonoids 2 and 3 and trans-stilbene 4 were deemed inactive according to the adopted mortality limit, additional tests revealed their ability to cause 65% Ae. aegypti larvae mortality, suggesting they could contribute to the larvicidal activity. Compound 5, identified by liquid chromatography-MS, was over eight-fold more toxic to larvae than the crude extract after 24 h. Therefore, 5 constitutes a structural model for new prototypes to control Ae. aegypti. These data reinforce the potential of natural products as a source of commercial alternatives for vector control strategies, respecting both sustainability and eco-friendly principles. © 2020 Society of Chemical Industry.
Keyphrases
- aedes aegypti
- zika virus
- dengue virus
- mass spectrometry
- liquid chromatography
- cardiovascular events
- oxidative stress
- risk factors
- multiple sclerosis
- simultaneous determination
- type diabetes
- electronic health record
- single cell
- high resolution mass spectrometry
- tandem mass spectrometry
- machine learning
- big data
- drosophila melanogaster