R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Munehisa ShimamuraHiroki HayashiNan JuShota YoshidaSatoshi BabaTsutomu SasakiHideki MochizukiRyuichi MorishitaHironori NakagamiPublished in: Stroke (2023)
RSPO3/LGR4 signaling plays a critical role in regulating TLR-induced inflammation and neurite outgrowth in the ischemic brain. Enhancing this signal will be a promising approach for treating ischemic stroke.
Keyphrases
- cerebral ischemia
- oxidative stress
- resting state
- white matter
- ischemia reperfusion injury
- immune response
- high glucose
- functional connectivity
- toll like receptor
- inflammatory response
- subarachnoid hemorrhage
- diabetic rats
- brain injury
- endothelial cells
- drug induced
- insulin resistance
- blood brain barrier
- skeletal muscle