Our data suggests that Pi4p/Nlrp3 in macrophages play an important role in the exacerbation of atherosclerosis in diabetic mice. Pi4p-related metabolizing enzymes (PI4KB and SAC1) may be a potential therapeutic strategy for diabetic atherosclerosis, and macrophage therapy is also a potential treatment.
Keyphrases
- signaling pathway
- type diabetes
- cardiovascular disease
- chronic obstructive pulmonary disease
- wound healing
- adipose tissue
- epithelial mesenchymal transition
- stem cells
- pi k akt
- machine learning
- high fat diet
- big data
- high fat diet induced
- risk assessment
- human health
- artificial intelligence
- deep learning
- data analysis
- combination therapy