Ectopic accumulation of ceramide in cardiomyocytes modulates alcoholic cardiomyopathy via the TLR4-dependent pathway.

Cui WangSongtao LiQingsheng LiuQianyu QianAi FuLin ChenLei ZhangToshinobu SuzakiZhiLing YuXiaobing Dou

Published in: Alcoholism, clinical and experimental research (2022)

Our findings demonstrate that ceramide accumulation plays a crucial role in alcoholic cardiomyopathy, effects that are partially mediated through the TLR4-dependent pathway.

Keyphrases

toll like receptor
inflammatory response
heart failure
liver injury
immune response
drug induced
nuclear factor
endothelial cells
atrial fibrillation