Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora.
Chuan-Zhi ZhuBin-Yuan HuJia-Wang LiuYi CaiXin-Chun ChenDa-Peng QinYong-Xian ChengZong-De ZhangPublished in: Molecules (Basel, Switzerland) (2019)
Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5-7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.
Keyphrases
- drug resistant
- multidrug resistant
- mycobacterium tuberculosis
- high resolution
- endothelial cells
- acinetobacter baumannii
- induced apoptosis
- escherichia coli
- magnetic resonance
- oxidative stress
- machine learning
- cell cycle arrest
- dendritic cells
- deep learning
- mass spectrometry
- computed tomography
- electron microscopy
- cell death
- density functional theory
- cell proliferation
- immune response
- molecular dynamics
- solid state
- contrast enhanced