Adiponectin inhibits inflammatory cytokines production by Beclin-1 phosphorylation and B-cell lymphoma 2 mRNA destabilization: role for autophagy induction.

Published in: British journal of pharmacology (2018)

Beclin-1 phosphorylation and Bcl-2 mRNA destabilization mediated by DAPK1 and TTP are crucial events leading to autophagy and the suppression of inflammatory cytokine production by gAcrp. These results provide novel mechanisms underlying adiponectin's modulation of inflammatory responses. DAPK and TTP are potential therapeutic targets for the management of inflammation.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
metabolic syndrome
signaling pathway
insulin resistance
protein kinase
diffuse large b cell lymphoma
binding protein
adipose tissue
human health
skeletal muscle
risk assessment