Association between single nucleotide polymorphisms in DNA repair genes and the efficacy of radiotherapy in nasopharyngeal carcinoma patients.

Rajaa BenzeidAmin GihbidNezha TawfikNadia BenchakrounKarima BendahhouAbdellatif BeniderAmal GuensiNaima El BennaAbdelkarim Filali MaltoufMohammed El MzibriMohammed AttalebMeriem KhyattiImane Chaoui

Published in: Contemporary oncology (Poznan, Poland) (2023)

The present study suggests that XRCC1 Arg399Gln polymorphism does not have any impact on the radio-therapeutic response in Moroccan NPC patients whereas XRCC3 Thr241Met polymorphism may act as a prognostic indicator for NPC patients treated with radiotherapy. However, studies with a larger sample are needed to confirm our results.

Keyphrases

dna repair
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
early stage
radiation therapy
peritoneal dialysis
gene expression
squamous cell carcinoma
locally advanced
oxidative stress
radiation induced
dna damage response
tyrosine kinase
patient reported