Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis.

Yukiko IwasakiYusuke TakeshimaMasahiro NakanoMai OkuboMineto OtaAkari SuzukiYuta KochiTomohisa OkamuraTakaho EndoIchiro MikiKazuhiro SakuradaKazuhiko YamamotoKeishi Fujio

Published in: Rheumatology (Oxford, England) (2022)

Plasma His levels are a potential biomarker for SLE patients and are associated with damage accrual. Our data suggest the importance of His as a pathogenic metabolite in SLE pathogenesis.

Keyphrases

systemic lupus erythematosus
disease activity
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
oxidative stress
rheumatoid arthritis
electronic health record
machine learning