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Adapting isotonic dose-finding to a dynamic set of drug combinations with application to a phase I leukemia trial.

Nolan A WagesDaniel R ReedMichael K KengMark R ConawayGina R Petroni
Published in: Clinical trials (London, England) (2021)
The aim of this article is to bring to light examples of novel design applications as a means of augmenting the implementation of innovative designs in the future and to demonstrate the flexibility of adaptive designs in satisfying changing design conditions.
Keyphrases
  • primary care
  • healthcare
  • clinical trial
  • acute myeloid leukemia
  • study protocol
  • bone marrow
  • phase iii
  • current status
  • phase ii
  • quality improvement
  • emergency department