Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro.

Selvi KunnimalaiyaanVictoriana K SchwartzIris Alao JacksonT Clark GamblinMuthusamy Kunnimalaiyaan

Published in: BMC cancer (2018)

LY2090314 effectively reduces growth of both human MYCN amplified and non-amplified NB cell lines in vitro. To our knowledge, this is the first study to look at the effect of LY2090314 in NB cell lines. These results indicate that GSK-3 may be a therapeutic target for NB and provide rationale for further preclinical analysis using LY2090314.

Keyphrases

signaling pathway
endothelial cells
pi k akt
healthcare
cell death
stem cells
cell therapy
induced pluripotent stem cells
cell proliferation
bone marrow
anti inflammatory