Investigation of cell culture conditions for optimal foot-and-mouth disease virus production.
Veronika DillAline ZimmerMartin BeerMichael EschbaumerPublished in: BMC biotechnology (2019)
The reasons for the diminished viral growth, if no complete media exchange has been performed prior to infection, remain unclear and further studies are necessary to investigate the causes more deeply. For now, the results argue for a vaccine production process with 100% media exchange to reliably obtain high viral titers.
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