A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature.
Scott F SchoningerYamen HomsiAlexandra KrepsNatasa MilojkvovicPublished in: Case reports in rheumatology (2018)
Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. We report a case of a 58-year-old male who presented with symmetrical inflammatory polyarthritis and was misdiagnosed with seronegative rheumatoid arthritis (RA). After failing many RA treatments and with further workup, the diagnosis of MM was made. This rare manifestation of MM carries a diagnostic challenge and causes a significant delay in treating such patients. Here, we report this unusual initial presentation with review of several cases in the English literature describing similar presentations.
Keyphrases
- rheumatoid arthritis
- multiple myeloma
- disease activity
- systematic review
- end stage renal disease
- cell proliferation
- chronic kidney disease
- ankylosing spondylitis
- interstitial lung disease
- ejection fraction
- chronic pain
- prognostic factors
- systemic lupus erythematosus
- oxidative stress
- peritoneal dialysis
- sleep quality
- cell cycle
- spinal cord injury
- patient reported outcomes
- body composition
- bone loss