Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode.

Alex Gonzalez Segura Gisela Mezquida Albert Martínez-Pinteño Patricia GassóNatalia RodriguezLucía Moreno-IzcoSilvia Amoretti Miquel BioqueAntonio LoboAna M González-Pinto Alicia García-AlconAlexandra Roldán-BejaranoEduard Vieta Elena de la Serna Alba Toll Manuel J Cuesta Sergi Mas Miguel Bernardonull null

Published in: Psychological medicine (2022)

Our study provides novel evidence of the polygenic bases of psychosis and its clinical manifestation in its first stage. The consistent effect of cognitive PRSs on the early clinical progression suggests that the mechanisms underlying the psychotic episode and its severity could be partially independent.

Keyphrases

bipolar disorder