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Novel evidence of ghrelin and growth hormone segretagogue receptor expression by human ocular tissues.

Alessia Di FonsoBarbara GhinassiPascal IzzicupoRoberta ZappacostaMarcella LiberatoreCarla Enrica GallengaMaria Angela D'AmicoPier Enrico GallengaAngela Di Baldassarre
Published in: Regulatory peptides (2014)
This study provides the first evidence that Ghr and GHSR-1a are expressed in the human eye by specific cells. The understanding of the functional role of Ghr at the human eye level needs more efforts and investigation, but a hypothetical action on the GH retinal synthesis and/or on the circadian clock system could be suggested.
Keyphrases
  • endothelial cells
  • growth hormone
  • induced pluripotent stem cells
  • gene expression
  • induced apoptosis
  • cell proliferation
  • quality improvement
  • optic nerve
  • endoplasmic reticulum stress