Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise.
Vinita ChauhanDanielle BeatonKnut Erik TollefsenR Julian PrestonJulie Jane BurttJulie LeblancNobuyuki HamadaEdouard I AzzamOlivier ArmantSimon BoufflerOmid AzimzadehSimone MoertlYutaka YamadaIgnacia Braga TanakaJan Christian KaiserKimberly E ApplegateDominique LaurierJacqueline Garnier-LaplacePublished in: International journal of radiation biology (2024)
By addressing the 25 priority questions, it is anticipated that constructed AOPs will have a high level of specificity, making them valuable tools for simplifying and prioritizing complex biological processes for use in developing revised radiation hazard and risk assessment strategies.