Distinct anti-proliferative effects of herbal melanin on human acute monocytic leukemia THP-1 cells and embryonic kidney HEK293 cells.

Adila El-ObeidHala AlajmiMashael HarbiWesam Bin YahyaHamad Al-EidiMonira AlaujanAdil HaseebThadeo TrivilegioAlshaimaa AlhallajSaleh AlghamdiAbdul-Wali AjlouniSabine Matou-Nasri

Published in: BMC complementary medicine and therapies (2020)

HM exerts distinct anti-proliferative effects on human acute monocytic leukemia and embryonic kidney cells mainly through cell cycle interference in a TLR4-independent manner and through apoptosis induction in a TLR4-dependent manner, as observed in only the THP-1 cells.

Keyphrases

cell cycle arrest
induced apoptosis
cell cycle
endoplasmic reticulum stress
endothelial cells
cell death
oxidative stress
immune response
bone marrow
liver failure
cell proliferation
signaling pathway
hepatitis b virus