A Physiologic Roll for Cell Surface GlycoRNAs.
William A MullerPublished in: Journal of leukocyte biology (2024)
Glycosylated RNA molecules (glycoRNAs) that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent paper (PMID 38262409) demonstrates that at least one function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycoRNAs bind to P-selectin, but not E-selectin.