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A Physiologic Roll for Cell Surface GlycoRNAs.

William A Muller
Published in: Journal of leukocyte biology (2024)
Glycosylated RNA molecules (glycoRNAs) that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent paper (PMID 38262409) demonstrates that at least one function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycoRNAs bind to P-selectin, but not E-selectin.
Keyphrases
  • cell surface
  • biofilm formation
  • pseudomonas aeruginosa
  • staphylococcus aureus
  • cystic fibrosis