Standardizing urethral stricture models in rats: a comprehensive study on histomorphologic and molecular approach.

Osman Ergün Muhammet Yusuf Tepebasi İbrahim Onaran Sefa Alperen Öztürk Mücahit Baltik Pinar Aslan Koşar

Published in: International urology and nephrology (2024)

Developing electrocoagulation-induced urethral stricture in rats is a simple, reliable, inexpensive, and reproducible. Reporting histologic data with qualitative and semi-quantitative scoring will enhance data standardization, aiding reader understanding and analysis. Transforming growth factor β and Platelet-derived growth factor play key roles in fibrosis during stricture development. Incorporating these cytokines in urethral stricture animal model studies can demonstrate successful stenosis creation.

Keyphrases

growth factor
transforming growth factor
endoscopic submucosal dissection
urinary incontinence
epithelial mesenchymal transition
electronic health record
big data
high glucose
systematic review
emergency department
adverse drug
drug induced
case control
endothelial cells