Re-annotation of the Theileria parva genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved pathway in many organisms.
Kyle TretinaRoger PelleJoshua OrvisHanzel T GotiaOlukemi O IfeonuPriti KumariNicholas C PalmateerShaikh B A IqbalLindsay M FryVishvanath M NeneClaudia A DaubenbergerRichard P BishopJoana C SilvaPublished in: BMC genomics (2020)
The process of re-annotation led to novel insights into the organization and expression profiles of protein-coding sequences in this parasite, and uncovered a minimal N-glycosylation pathway that changes our current understanding of the evolution of this post-translational modification in apicomplexan parasites.