Association of Clinical Aspects and Genetic Variants with the Severity of Cisplatin-Induced Ototoxicity in Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study.

Lígia Traldi MacedoEricka Francislaine Dias CostaBruna Fernandes CarvalhoGustavo Jacob LourençoLuciane CalongaArthur Menino CastilhoCarlos Takahiro ChoneCarmen Silvia Passos Lima

Published in: Cancers (2023)

Our data present, for the first time, the association of combined inherited nucleotide variants involved in CDDP efflux, DNA repair, and apoptosis with ototoxicity, which could be potential predictors in future clinical and genomic models.

Keyphrases

dna repair
dna damage
copy number
oxidative stress
endoplasmic reticulum stress
electronic health record
dna damage response
gene expression
risk assessment
cell cycle arrest
cell proliferation