Anatomical-MRI Correlations in Adults and Children with Hypertrophic Cardiomyopathy.
Radu Ovidiu RosuAna LupsorAlexandru NeculaGabriel CismaruSimona Sorana CainapDaniela IacobCecilia LazeaCosmin Andrei CismaruAlina-Gabriela NegruDana PopGabriel GusetuPublished in: Diagnostics (Basel, Switzerland) (2022)
Hypertrophic Cardiomyopathy (HCM) is the most frequent hereditary cardiovascular disease and the leading cause of sudden cardiac death in young individuals. Advancements in CMR imaging have allowed for earlier identification and more accurate prognosis of HCM. Interventions aimed at slowing or stopping the disease's natural course may be developed in the future. CMR has been validated as a technique with high sensitivity and specificity, very few contraindications, a low risk of side effects, and is overall a good tool to be employed in the management of HCM patients. The goal of this review is to evaluate the magnetic resonance features of HCM, starting with distinct phenotypic variants of the disease and progressing to differential diagnoses of athlete's heart, hypertension, and infiltrative cardiomyopathies. HCM in children has its own section in this review, with possible risk factors that are distinct from those in adults; delayed enhancement in children may play a role in risk stratification in HCM. Finally, a number of teaching points for general cardiologists who recommend CMR for patients with HCM will be presented.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- magnetic resonance
- cardiovascular disease
- young adults
- risk factors
- end stage renal disease
- heart failure
- high resolution
- blood pressure
- chronic kidney disease
- contrast enhanced
- type diabetes
- prognostic factors
- newly diagnosed
- metabolic syndrome
- copy number
- gene expression
- computed tomography
- atrial fibrillation
- mass spectrometry
- cardiovascular events
- current status
- patient reported outcomes
- middle aged